MOG and neuromyelitis optica: MOG-antibody disease has only recently been recognized as a distinct clinical entity. The disease can onset throughout life, with a median age of onset in the early 30s. It is slightly more common in women. Symptoms include optic neuritis, myelitis, or acute disseminated encephalomyelitis. The course of disease can be monophasic or relapsing. The outcomes tend to be better than in NMO.