IFN-γ exhibits a protective effect in IA by the following mechanisms: (1) reducing inflammatory cell death by targeting necroptosis (18); (2) inhibiting IL-1β-induced matrix metalloproteinase (MMP) synthesis by RA FLSs, thereby limiting cartilage degradation (19); and (3) and inhibiting Th17 cell development and suppressing Th17 cell effector functions (20). The gene discussed is IFNG; the disease is rheumatoid arthritis.