(1) CII-reactive MZB cells exhibit spontaneous IgM and significant APC capacity for murine arthritis development;(2) B10 is crucial for suppression of Th1/Th17 response and induction of T regulatory type 1 cells;(3) B10 directly inhibit Th17 cells generation via reduction of STAT3 phosphorylation and RORγt expression;(1) B10 present CD1d-lipid and induced iNKT cells to secrete IFN-γ to ameliorate arthritis. This evidence concerns the gene CD1D and arthritic joint disease.