Hsp65-lac treated mice had lower levels of IL-17 and IFN-γ (Figure 3) in cell cultures of spleen (Figures 3A,D), and mesenteric lymph nodes (Figures 3B,E) stimulated with collagen throughout arthritis development as well as in cultures of inguinal lymph node cells (Figures 3C,F) at day 95. The gene discussed is IL17A; the disease is arthritic joint disease.