SOCS3 and acute pancreatitis: Recent studies on acute pancreatitis have also shown that LPS up-regulates the expression levels of SOCS1 and SOCS3 in acinar cells, while SOCS1 and SOCS3 directly interact with TRAF6 and degrade TRAF6 protein through polyubiquitination, thereby counteracting the protective function of TRAF6 in the inflammatory response (97).