Similar reports have been reported in flaviviruses, ZIKV infection causes up-regulated expression of SOCS1 and SOCS3, thereby inhibiting RLR dependent IFN-I and IFN-III secretion, indicating that in ZIKV infection, SOCS proteins may regulate viral replication by modulating the antiviral innate immune response (138). The gene discussed is CISH; the disease is Zika virus infectious disease.