Similar reports have been reported in flaviviruses, ZIKV infection causes up-regulated expression of SOCS1 and SOCS3, thereby inhibiting RLR dependent IFN-I and IFN-III secretion, indicating that in ZIKV infection, SOCS proteins may regulate viral replication by modulating the antiviral innate immune response (138). This evidence concerns the gene SOCS1 and Zika virus infectious disease.