TLR4 and autoimmune disease: In addition, studies have shown that MRL-1pr/lpr mice (a Th1-mediated autoimmune disease model) after oral administration of HA900 (a high molecular weight hyaluronic acid) can up-regulate SOCS3 expression in colorectal epithelial cells through TLR4, thereby regulating Th1-mediated autoimmune diseases and inflammation (99).