To exclude the effect of TCR specificity, we adoptively transferred CD8+ T cells from P14 mice, which carried an engineered TCR specifically recognizing the H-2Db-restricted GP33 epitope derived from LCMV glycoprotein (amino acids 33–41; KAVYNFATC), into congenic naive mice, followed by infection with LCMV Clone 13 (Figure 3A). This evidence concerns the gene CD8A and infection.