Intriguingly, chronic i.c.v. leptin injection did not reverse hyperglycemia in insulin-deficient RIP-CreΔLEPR mice (Figures 2B,C), suggesting that LEPRs in RIP-Cre25Mgn neurons play a critical role in glucose-lowering effects of leptin in an insulin-independent manner. The gene discussed is LEP; the disease is Hyperglycemia.