LEP and Hyperglycemia: I.p. administration acipimox into RIP-CreΔLEPR-LEP (two times per day for 5 days) 10 days after leptin administration initiated (Figure 6C) significantly improved hyperglycemia RIP-CreΔLEPR-LEP (RIP-CreΔLEPR-LEP-Acip) compared to the control group (RIP-CreΔLEPR-LEP-Sal) (Figure 6D), along with the improvements of blood FFAs levels (Supplementary Figure 4A).