When exposed to high intake of dietary lipids, the liver of OVX female mice displays increased expression of Mcp-1 (monocyte chemoattractant protein-1) and Ccr2 (monocyte chemokine receptor 2) that trigger the recuitment of macrophages and promote hepatic fibrosis, endoplasmic reticulum stress and apoptosis, all changes that are improved by estradiol treatment (264). This evidence concerns the gene CCL2 and Hepatic fibrosis.