NFKB1 and metabolic dysfunction-associated steatohepatitis: NF-κB and its downstream signaling pathway are under the inhibitory control of estrogen signaling (255–257), a regulation that accounts for sex- and menopause-associated over-regulation of hepatic inflammatory process and for the progression of NAFLD toward more harmful conditions such as NASH, fibrosis and HCC (16, 49, 230, 258, 259).