NFKB1 and metabolic dysfunction-associated steatotic liver disease: In NAFLD, the increased flux of FFAs, the generation of lipotoxicity and oxidative stress and insulin resistance concur in activating JNK and NF-κB signaling pathways, resulting in the increased production of pro-inflammatory cytokines, including IL-6 and TNF-α (4, 48, 49, 246).