INS and Insulin resistance: Modern western diets are particularly enriched in saturated and trans FAs that are particularly detrimental for hepatic health, because they induce insulin resistance and fatty liver and promote liver injury by altering the composition of plasma cell membrane, thus impairing cellular homeostasis and amplifying the already sustained inflammatory signaling, that, in turn, boosts insulin resistance and apoptosis (127, 128, 131, 132).