INS and metabolic dysfunction-associated steatotic liver disease: Sex-specific and estrogen-mediated differences in obesity-induced NAFLD are ascribable also to impaired regulation of metabolic process in extrahepatic tissues showing a cross-talk with the liver, such as the adipose tissue and the skeletal muscle, that under obesogenic conditions display increased insulin resistance and increased inflammation that might further aggravate the hepatic dysmetabolism (96–106).