In the adipose tissue of obese people, the infiltration and activation of immune cells (macrophages, B-lymphocytes, T-lymphocytes and neutrophils) that produce pro-inflammatory cytokines (e.g., interleukin 1β, IL-1β; interleukin 6, IL-6; tumor necrosis factor-alpha, TNF-α) impair the dynamic antagonism between adipokines and cytokines and facilitate the progression of steatosis, inflammation and fibrosis (82). The gene discussed is TNF; the disease is steatosis.