PCK2 and Hyperglycemia: An example could be the use of the G6P- or PEPCK-promoters in liver cells to monitor hyperglycemia (74, 75), or a Runt-related transcription factor (Runx)2-driven promoter in osteoblasts or Smad-driven promoters in osteoclasts as markers for GC-induced osteoporosis (76, 77).