In conclusion, the FGF21-Adiponectin Ratio was associated with NAFLD status, and there was a positive correlation between FAR and final liver fat, even after controlling for sex and pubertal stage, in those with NAFLD at baseline as determined by repeated MRI scans before and after a 6-month lifestyle intervention. The gene discussed is FGF21; the disease is metabolic dysfunction-associated steatotic liver disease.