POMC and Adrenal insufficiency: An evaluation of the adrenal function in the 35 patients with available data showed that only 4 (11.4%) patients had baseline cortisol (17.64, 120.4, 79.24, and 94.86 nmol/L, respectively), and ACTH levels (216.2, 391.0, 219.9, and 325 pmol/L, respectively), that were suggestive of adrenal insufficiency, including 3 (8.5%) patients with bilateral adrenal involvement and 1 (2.9%) patient with unilateral adrenal involvement.