Mouse models that express wild-type 3R and 4R human tau isoforms in appropriate ratios recapitulate the same cell type vulnerabilities that typify human tauopathies when injected with human tau extracts, including the development of tufted astrocytes in PSP tau-injected mice, and astroglial plaques in CBD tau-injected mice (81). This evidence concerns the gene MAPT and tauopathy.