APP and Alzheimer disease: A newly published study that transplanted gut microbiota from AD patients to either APP/PS1 mice, a double transgenic mouse that carries chimeric mouse/human amyloid precursor protein (APP) and human presenilin 1 (PS1) mutations associated with familial AD, or wild type mice, demonstrated that the transplantation of the gut microbiome of an AD patient can influence AD pathology and Nlrp3 inflammasome activation.