MAPT and Alzheimer disease: Several inflammasomes have been implicated in neurodegenerative diseases, the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome in particular has been shown to play a key role in the development and progression of Aβ-plaque formation as well as tau-induced pathology, which has been demonstrated in both post-mortem AD patient brain tissue and in vivo/in vitro transgenic mouse studies (37–42).