A newly published study that transplanted gut microbiota from AD patients to either APP/PS1 mice, a double transgenic mouse that carries chimeric mouse/human amyloid precursor protein (APP) and human presenilin 1 (PS1) mutations associated with familial AD, or wild type mice, demonstrated that the transplantation of the gut microbiome of an AD patient can influence AD pathology and Nlrp3 inflammasome activation. Here, NLRP3 is linked to Alzheimer disease.