This is particularly true in light of current advanced technologies integrated into the daily diabetes care regimen with related rules and calculations (i.e., carbohydrate counting as a meal planning approach with portion control, rules to estimate insulin bolus dosages based on an insulin-to-carbohydrate ratio, setting of the individual’s correction factor, etc.)that may further increase continuous attention to food intake and to body functioning. The gene discussed is INS; the disease is diabetes mellitus.