Theoretical models of DEB risk in T1D, such as the Modified Dual Pathway (Peterson et al., 2018; Rancourt et al., 2019), also recognized the role of body dissatisfaction along with the physiological disease processes and treatment-based factors (i.e., weight gain resulting from insulin therapy, hunger/satiety dysregulation, frequent blood glucose fluctuations, dietary regimen), or some combination of them, in predisposing youth with T1D to engage in unhealthy compensatory weight control behaviors (e.g., bulimic symptoms). The gene discussed is INS; the disease is type 1 diabetes mellitus.