Deficits in hippocampal-dependent spatial memory and spontaneous seizures are observed in mice with conditional transgenic expression of dominant-negative mutant Kv7.2-G279S (Peters et al., 2005) and heterozygous knock-in mice for Kv7.2 containing epileptic encephalopathy loss-of-function variant T274M (Milh et al., 2020). The gene discussed is KCNQ2; the disease is Epileptic encephalopathy.