MAPK8 and hemorrhagic stroke: Interestingly, attenuation of JNK activation via SP600125 administration increased microglial cell death (Ohnishi et al., 2007), and reduced the pro-inflammatory response following SAH notably by decreasing the levels of IL6 in the CSF during the early brain injury phase as well as the second phase of hemorrhagic stroke in dogs (Yatsushige et al., 2005).