In a recent study, the depletion of profilin-1 (Pfn1), which is an actin-binding protein involved in the dynamic transformation and reorganization of cytoskeleton, attenuated damage upon cerebral ischemia via modulation of microglial cell function associated with the RHOA/ROCK pathway (Lu et al., 2020). The gene discussed is PFN1; the disease is Cerebral ischemia.