VEGFA and brain ischemia: Galangin, a natural flavonoid isolated from the rhizome of Alpinia officinarum Hance, has been shown as well to improve neurovascular functions after cerebral ischemia, and to ameliorate neurological functions through activation of the canonical Wnt pathway coupled with hypoxia-inducible factor-1α (HIF1α) and vascular endothelial growth factor (VEGF) (Wu et al., 2015).