De Macedo et al. (2015) showed that activation of ACE2 using diminazene aceturate had a significant effect on lipogenesis. In vitro, we found that SREBP1 expression is also upregulated in lung epithelial cells of obese subjects compared to non-obese subjects. In studies in chronic kidney disease it has been shown that angiotensin II activates SREBP1 which mediates angiotensin II–induced profibrogenic responses (Wang T.N. et al., 2015). Here, ACE2 is linked to chronic kidney disease.