Hence, there may occur a shift in the time frame of events between both mouse strains: the increase in blood pressure by AngII infusion (measured in Atg7+/+ SM22α-Cre+ mice, passed over in Atg7F/F SM22α-Cre+ animals) precedes cardiac hypertrophy (to occur in Atg7+/+ SM22α-Cre+ and measured in Atg7F/F SM22α-Cre+). Here, ATG7 is linked to cardiac hypertrophy.