A growing amount of evidence suggests that supplemental H2S, especially in multiple disease models such as diabetes, hypertension, atherosclerosis, and heart/renal ischemia/reperfusion injury, can reduce oxidative stress, reduce levels of proinflammatory cytokine circulation interleukin-1β (IL-1β) and Chemokine (C-C motif) ligand 2 (CCL2), and regulate cellular redox balance, thereby reducing disease risk (Yang et al., 2011). The gene discussed is CCL2; the disease is hypertensive disorder.