Even though the exact link between diabetes mellitus and cognitive impairment is not fully elucidated, some authors have revealed that hyperglycemia, vascular disease (Fusco et al., 2019; Impellizzeri et al., 2019), hypoglycemia, insulin resistance, and amyloid deposition can be associated with cognitive dysfunction, especially in elderly people (Kodl and Seaquist, 2008). Here, INS is linked to Hyperglycemia.