At the same time, Groh et al. (2013) mentioned that polyphenols, such as epigallocatechin-3-gallate and genistein potently diminished the activity of HDAC in intact colon carcinoma cells and demonstrated that the modulation of HDAC activity is associated with the suppression of HDAC1. The gene discussed is HDAC1; the disease is colon carcinoma.