Even though the exact link between diabetes mellitus and cognitive impairment is not fully elucidated, some authors have revealed that hyperglycemia, vascular disease (Fusco et al., 2019; Impellizzeri et al., 2019), hypoglycemia, insulin resistance, and amyloid deposition can be associated with cognitive dysfunction, especially in elderly people (Kodl and Seaquist, 2008). Here, INS is linked to diabetes mellitus.