TNF and age: Some authors revealed that polyphenol administration may prevent neurodegeneration, inhibit inflammations and reduce age – related cognitive decline by scavenging free radicals, activating various signaling pathways, modulating gene expression, down-regulating NFkB and nuclear factor erythroid 2-related factor 2 (Nrf2) or inhibiting the release of cytokines (IL-1β, TNF-α) (Spencer et al., 2009; González-Gallego et al., 2010; Vauzour, 2012; Vauzour, 2017).