Preliminary results indicate that WVBF can regulate the NRF2 pathway, WVBF treatment of NAFLD cells increased intracellular Nrf2 expression in a dose-dependent manner, suggesting that the antioxidant potential of WVBF could be an important mechanism for improving liver function of NAFLD cells, which is similar to the results of our previous study (Dai et al., 2018). This evidence concerns the gene NFE2L2 and metabolic dysfunction-associated steatotic liver disease.