Poria cocos bark extract ameliorated the symptoms of food allergy (FA) and atopic dermatitis (AD) and increased the levels of Th2-related cytokines and the population of Foxp3+CD4+ Tregs in both AD and FA, revealing that PCB extract could be a novel oral immunosuppressive agents for treating AD and FA through the production of Tregs (Bae et al., 2016). Here, CD4 is linked to Alzheimer disease.