GLT8D2 and fatty liver disease: For example, the T-synthase (a glycosyltransferase) gene protected mice from fatty liver disease (Fu et al., 2008); the formation of bisecting-GlcNAc lead to the generation of fatty liver by disrupting the function of apolipoprotein B (Ihara et al., 1998); Glycosyltransferase GLT8D2 regulates ApoB100 protein expression in hepatocytes and participates in NAFLD pathogenesis (Wei et al., 2013a; Zhan et al., 2015).