MAPT and Alzheimer disease: The diversity of biological tau functions is mainly regulated by phosphorylation that attracted much attention as a modification particularly relevant for the propagation of AD pathology (Jazvinšćak Jembrek et al., 2013; Alavi Naini and Soussi-Yanicostas, 2015; Šimić et al., 2016; Barbier et al., 2019; Miao et al., 2019).