MAPT and tauopathy: In brain tissue of Tg mouse models and in extracted PHFs form cortical regions of various human 4R or 3R/4R tauopathies, increased levels of acetylation, specifically at Lys274 and Lys280, were observed in pathologically insoluble, hyperphosphorylated tau aggregates (Cohen et al., 2011; Alavi Naini and Soussi-Yanicostas, 2015).