These kinases phosphorylate tau at multiple serine and threonine residues known to be implicated in AD, and their overexpression or activation induces tauopathy-characteristic phenotypes (Terwel et al., 2008; Kremer et al., 2011; Jazvinšćak Jembrek et al., 2013; Llorens-Martín et al., 2014). This evidence concerns the gene MAPT and tauopathy.