MAPT and tauopathy: Indeed, numerous studies have demonstrated that intracranial injections of tau strains derived from distinct tauopathies into healthy wild-type animals resulted in the development of patterns of tau pathology similar to the source tauopathy (Clavaguera et al., 2013; Sanders et al., 2014; Boluda et al., 2015; Kaufman et al., 2016; Narasimhan et al., 2017).