MAPT and tauopathy: Seed-competent tau monomers have been reported to form morphologically distinct “strains” in different tauopathies, meaning that a conformation of tau in a given seed will define the distinct type of inclusions, rate of spread, and pattern of the neuropathological lesion in each disease (Sanders et al., 2014; Kaufman et al., 2016; Narasimhan et al., 2017; Sharma et al., 2018).