For instance, expression of the ALS mutants of RNA-binding protein TDP-43 showed decreased mobility of axonal RNPs and reduced axonal transport in motor neurons (Alami et al., 2014), and ALS-causing TDP-43 mutations alter the axonal content of both mRNAs and miRNAs in cultured spinal motor neurons (Rotem et al., 2017). Here, TARDBP is linked to amyotrophic lateral sclerosis.