Indeed, mutations in the motor or neck domain are associated with CMT2 and HSP, while a mutation of KIF5A C-terminus and a mutation that affect splicing are linked to an intermediate slowly progressive form of ALS (Brenner et al., 2018; Citrigno et al., 2018; Filosto et al., 2018; Nam et al., 2018). The gene discussed is KIF5A; the disease is amyotrophic lateral sclerosis.