NFASC and amyotrophic lateral sclerosis: Alteration in the stoichiometry of NF subunits has been linked to ALS, while NF side arm phosphorylation is induced by excitotoxic glutamate-mediated activation of JNK, p38 and CDK-p25 kinase (Bajaj and Miller, 1997; Ackerley et al., 2000, 2004).