TARDBP and amyotrophic lateral sclerosis: Also, TAR DNA-binding protein 43 (TDP-43), one of the key proteins identified in ALS patients neuronal inclusions, can interact with the neuronal cytoskeleton (reviewed in Oberstadt et al., 2018; Hergesheimer et al., 2019), has been shown to alter the stability of NF-L mRNA when mutated (Volkening et al., 2009; Prasad et al., 2019) and impair trafficking and anterograde transport of messenger ribonucleoprotein (mRNP) granules (Alami et al., 2014).