Indeed, mutations of the small heat shock protein HSPB1 and HSPB8 cause distal hereditary motor neuropathy (dHMN) and CMT, and are associated with cytoskeletal abnormality (d’Ydewalle et al., 2011; Irobi et al., 2012; Bouhy et al., 2018). Here, HSPB8 is linked to distal hereditary motor neuropathy.