Interestingly, when human astroglia cells expressing IL4R in culture were activated by the ligand IL4, they showed active Type 2 IL4 signaling and enhanced proliferation, neurogenesis and neuronal network formation under Alzheimer’s disease conditions, which is reminiscent of the zebrafish Alzheimer’s model (Papadimitriou et al., 2018). This evidence concerns the gene IL4R and Alzheimer disease.