IL4R and early-onset autosomal dominant Alzheimer disease: Interestingly, when human astroglia cells expressing IL4R in culture were activated by the ligand IL4, they showed active Type 2 IL4 signaling and enhanced proliferation, neurogenesis and neuronal network formation under Alzheimer’s disease conditions, which is reminiscent of the zebrafish Alzheimer’s model (Papadimitriou et al., 2018).