In the ALS, the presence of mutant proteins (SOD1 and TDP-43), oxidative stress, mitochondrial damage, etc., produces continuous damage, which can trigger a chronic activation of glial cells and, therefore, a sustained inflammatory process that could exacerbate neuronal damage (Philips and Robberecht, 2011). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.