TNF and Alzheimer disease: Further, short sleep duration, greater wake after sleep onset (WASO), worse sleep efficiency, and greater of percentages of the sleep period with blood oxygen saturations below 90% are associated with increased IL-6, CRP, TNF-α, and interferon γ (INF- γ) in older adults and AD caregivers (Friedman et al., 2005; Von Kanel et al., 2006; Smagula et al., 2016).