A recent study conducted comprehensive histopathological analysis of tau inclusion, neurotransmitter synthesis, and neuronal loss in a series of brainstem wake-promoting nuclei in healthy controls and patients with a variety of tauopathies, including AD, corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP) (Oh et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.