Habitual poor sleep and chronic sleep deprivation are associated with increased tau burden, tau hyperphosphorylation, and the spread of tau pathology across brainstem and hippocampal circuits, resulting in degeneration and memory impairment (Rothman et al., 2013; Di Meco et al., 2014; Ju et al., 2017; Zhu et al., 2018; Holth et al., 2019). Here, MAPT is linked to memory impairment.