BACE1 and brain injury: BACE1 cleaves a variety of substrates (Hemming et al., 2009) and is associated with decreased dendritic spine integrity (Savonenko et al., 2008) and axonal blebbing (Hitt et al., 2012; Hu et al., 2015), which is due to an increase in the number of APP positive neuronal terminals (Tran et al., 2011) after brain trauma.