PSEN2 and Alzheimer disease: This study showed miR-21 or -214 elevation coupled with miRNA-328 or -135A suppression were associated with BACE1 and PSEN2 modulation, which is in accordance with former studies detailing suppression of BACE1 by miR-135A, miR-328, and miR-29c in cell cultures (Zong et al., 2011; Liu et al., 2014b) and transgenic mouse models of AD (Boissonneault et al., 2009).