MAPT and Alzheimer disease: The pathogenesis of AD is extremely complicated, mainly including the deposition of amyloid-β (Aβ) and hyperphosphorylation of tau protein, which results in the formation of Aβ-plaques and intracellular neurofibrillary tangles (NFTs) separately (Kidd, 1963; Hyman et al., 1984; Braak and Braak, 1991; Wegmann et al., 2010; Aisen et al., 2017), then causes neuronal death.