Our study demonstrated that at a tertiary care university hospital, inappropriate ordering of acute viral hepatitis serologies (anti-HAV IgM and anti-HBc IgM) was common, likely related to the incorporation of the acute viral serologies in the “hepatitis panel” without calling the panel an “acute hepatitis panel.” Despite 2 interventions resulting in statistically significant reductions in the rates of inappropriate testing, the rates of testing remained high and similar, whether the provider had to justify overriding the automatic alert or not. Here, CD40LG is linked to hepatitis A virus infection.