RUNX2 and colorectal carcinoma: Moreover, we first found that RUNX2 can bind to BRG1 and that the knockdown of BRG1 could markedly inhibit the RUNX2-mediated upregulation of the CD44 expression, suggesting that RUNX2 promotes the CD44 expression and EMT depending on the interaction between RUNX2 and BRG1 in CRC cells.