In addition, since it has been recently demonstrated that IRE1α is able to up-regulate its own transcription through a positive regulation loop57, evaluating Notch3 and IRE1α correlation at mRNA levels per se may represent an important feature of T-ALL-bearing patients that rely on UPR through the Notch3-IRE1α axis activation to survive, thus finally predicting a potential novel therapeutic target. The gene discussed is ERN1; the disease is acute lymphoblastic leukemia.