To assess the involvement of Notch proteins in the ER stress/UPR signaling network in T-ALL, ER stress induction by Tunicamycin treatment was performed in different human T-ALL cell lines, all constitutively expressing Notch1 and Notch3 at various levels (Supplementary Fig. S1a), and their survival was evaluated (Fig. 1a). The gene discussed is NOTCH3; the disease is acute lymphoblastic leukemia.