Notably, an in silico analysis of the Notch3 and IRE1α gene expression levels in two cohorts of T-ALL-bearing patients, collectively consisting of 317 individuals1,32 (Fig. 3e), highlighted a significant positive correlation between Notch3 and IRE1α gene expression levels, thus reinforcing the possible relationship between Notch3 and IRE1α proteins in T-ALL context. This evidence concerns the gene ERN1 and acute lymphoblastic leukemia.