PKM and cancer: In addition, PKM2 is known to be transcriptionally regulated by c-Myc, a well-known Wnt/β-catenin signalling target gene regulating the cancer metabolism.41 In addition, positive feedback regulations between PKM2 and c-Myc in the Warburg effect have been elucidated.29 However, we did not observe any noticeable correlation of its expression with PKM2 in various CRC cells.