PKM2 also reported to be regulated by EGF or EGFR, as shown by its upregulation and translocation into the nucleus followed by interaction with β-catenin for cell proliferation in brain tumours.35,40 However, in CRC cells, PKM2 is specifically upregulated by Wnt3a, and not EGF or bFGF. This evidence concerns the gene EGF and brain neoplasm.