The validated human CRC patient microarray data sets showed that the expressions of glycolytic genes including PKM and LDHA were co-increased with Wnt/β-catenin signalling target genes such as c-Myc, CCND1 (encoding Cyclin D1), and AXIN2 in CRCs compared to those expressed in adjacent normal tissues (Fig. S3b). Here, PKM is linked to colorectal carcinoma.