PKM2 also reported to be regulated by EGF or EGFR, as shown by its upregulation and translocation into the nucleus followed by interaction with β-catenin for cell proliferation in brain tumours.35,40 However, in CRC cells, PKM2 is specifically upregulated by Wnt3a, and not EGF or bFGF. Here, PKM is linked to colorectal carcinoma.