PKM and cancer: Among these, 50% (6 out of 12) are proteins involving cancer metabolism (Fig. 1b and Fig. S1a, b); PKM2, LDHA, and pyruvate kinase (PK) are glycolytic enzymes,29,30 and stress-70 protein (HSP70) and ATP synthase are associated with the regulation of oxidative phosphorylation.31 The reduction of PKM2, LDHA, and ATP synthase by KYA1797K was confirmed in DLD1 cells and several other CRC cell lines (Fig. 1c and Fig. S2).