CHL1 and psychiatric disorder: Particularly relevant to the pathophysiology of SZ and other psychiatric disorders are findings showing that ADAM10 is involved in the regulation of glutamatergic NMDA transmission in prefrontal cortex GABAergic neurons, specifically affecting the balance of synaptic/extrasynaptic NMDAR‐mediated signalling through the regulation of soluble polysialylated form of the neural cell adhesion molecule (polySia‐NCAM) (Varbanov & Dityatev, 2017).