TGIF1 and colorectal carcinoma: These data suggest a model (Fig. 6E, left panel) where the majority of LUAD SEs are associated with master TFs CRC (Fig. 6E, right panel) involving ELF3, EHF, and TGIF1, which with mediators provide a strong transcriptional complex for downstream oncogenes to accelerating aggravation of LUAD progression.