BCL2L1 and colorectal carcinoma: To further test whether intestinal epithelial cells are less prone to cell death induction via chemical BCL-XL inhibition compared to CRC cells, nontransformed human intestinal epithelial cells (CCD 841 CoN cell line) were treated with 20 μM WEHI-539, 20 μM ABT-199, or 20 μM S63845, representing the highest doses used for screening in human CRC cell lines (Fig. 2a).