While we previously identified a role for RNF40 in suppressing apoptosis in colorectal cancer cells via expression of antiapoptotic members of the BCL2 family of proteins19, our current results suggest that RNF40 supports HER2+-BC tumor viability and tumorigenic features in a distinct manner via maintenance of ROCK-dependent focal adhesion kinase signaling. Here, ERBB2 is linked to breast cancer.