ERBB2 and breast cancer: In accordance, stratifying HER2+-BC patients from The Cancer Genome Atlas (https://portal.gdc.cancer.gov/) according to RNF40 expression levels using publically available mRNA-seq data, we observed that RNF40low tumors are also enriched for the same “HALLMARK_APOPTOSIS” geneset (Fig. 3C, Fig. S3C).