As expected, we observed that CUDC-907 inhibited the PI3K pathway, as indicated by the dose-dependent decreases in phosphorylation of AKT and its downstream targets, p-4EBP-1, and p-S6RP in all SCLC cell lines tested (Fig. 1d & Supplementary Fig. 1). The gene discussed is EIF4EBP1; the disease is small cell lung carcinoma.