Abnormal GLUT-1 expression in cancer is regulated by various factors including hypoxia and altered MAPK and PI3K/AKT signalling pathways [94].Overexpression of GLUT1 was linked to radioresistance in both head and neck squamous cell carcinoma [95] and oral cavity squamous cell carcinoma [96] making it an attractive target for enhancing radiosensitivity. The gene discussed is SLC2A1; the disease is head and neck squamous cell carcinoma.