ASPH and cancer: Despite the combined evidence suggesting that AspH is a promising medicinal chemistry target for the development of small-molecule-based cancer therapeutics, comparatively few AspH inhibition studies using small-molecules are reported, with most of these relying either on the use of likely non-selective19, 20 or partially selective21 small-molecules or on the use of l-ascorbic acid (LAA)-derived small-molecules.18, 22, 23, 24 This likely reflects the historic lack of simple and reliable assays to monitor recombinant human AspH activity in vitro.