BCL2 and cancer: Strikingly, four of the most active eleven identified AspH inhibitors of the cancer API compound library are reported inhibitors of human anti-apoptotic B-cell lymphoma-2 (Bcl-2)34, 35 proteins (including Bcl-2, Bcl-XL, and Bcl-w): the (R)-enantiomer of the natural product gossypol (AT-101; Table 1, entry 2),37, 38, 39 Abbott-developed venetoclax43, 44 (ABT-199; Table 1, entry 4) and navitoclax49 (ABT-263; Table 1, entry 8), and the natural-product derived obatoclax51, 52 (GX15-070; Table 1, entry 11).