The upregulation of AspH and its translocalization from the endoplasmic reticulum (ER) membrane to the cell surface in cancer cells correlates with enhanced cell motility and metastatic spread resulting in a reduced lifespan of the affected patients.11, 12 Studies on naturally occurring mutations of human AspH presumably resulting in inactive AspH (Traboulsi syndrome)13, 14, 15, 16 and animal models8, 17, 18 suggest that AspH might affect cell motility through the notch signalling pathway. Here, ASPH is linked to cancer.