TARDBP and amyotrophic lateral sclerosis: The prion-like domain is not required for RNA- or DNA-binding activity, but is critical for alternative splicing of some mRNAs and for protein-protein interactions (104) The importance of this region for protein aggregation was reinforced by the observation that many of the ALS- and FTD-linked TDP-43 mutations lie in or near the prion-like domain.