Amongst those cases with laryngeal papilloma, IHC showed positive staining in 64.7% (22) of cases for p16.6 Similarly, Laco, et al. in their study for HPV infection and p16 expression in different laryngeal lesions, p16 expression was seen in 18 (78%) of 23 cases with laryngeal papilloma.7 In a study from Japan by Kiyuna, et al., only five (5.7%) of the 88 cases with laryngeal ca were p16 positive.8 All of those cases were male and also positive for high risk HPV. The gene discussed is CDKN2A; the disease is larynx squamous papilloma.