This increasing incidence is thought to be linked with HPV and is commonly seen in white men in fourth to fifth decades of life.15 HPV related oncogenesis is also associated with p16 overexpression due to inhibitory action of E6/E7 oncogenes on p53 and pRb.2,5 Association of p16 overexpression in HPV associated OPSCC is well studied and p16 overexpression is often taken as a surrogate maker for HPV infection.2,16 In this study, there were only two cases of oropharyngeal carcinoma and both were male and below 60 years. Here, CDKN2A is linked to oropharyngeal carcinoma.