Although in their study, 32 other cases also showed a diffuse nuclear and cytoplasmic staining, they didn't consider it positive as the staining was seen in <70% of the tumor cells.9 Similarly, in a study from China by Galera, et al. 18% of cases with laryngeal squamous cell carcinoma showed immunoreactivity for p16. Here, CDKN2A is linked to neoplasm.