EIF2AK3 and diabetes mellitus: Studies conducted in experimental animal models of diabetes (streptozotocin‐induced diabetes and db/db mice) have shown a sustained activation of UPR, with increased levels of phosphorylated PERK, eIF2α and CHOP, with activation of ATF6 and caspase with secondary glomerular and tubular cells apoptosis.55, 56, 57