Furthermore, the inhibitory signaling of CD200R1 expressed on infiltrating lymphocytes functions as a critical regulator of the peripheral immune response after brain injury, impacting mice's survival and susceptibility to poststroke infection (Ritzel et al., 2019); in contrast, the upregulation of CD200R1 can induce neuroprotective roles in inflamed brains (Hernangomez et al., 2012). Here, CD200R1 is linked to infection.