Based on these few evidences, we speculate that ANGPTL8 could act as an (healthy) hepatokine or (unhealthy) adipokine depending on the metabolic milieu, such that the correlation between ANGPTL8 and NAFLD seen in patients with PWS reflects a healthier metabolic status compared to controls matched for BMI SDS. This evidence concerns the gene ANGPTL8 and metabolic dysfunction-associated steatotic liver disease.