Evidence of abnormalities in the nuclear membrane and aggregation of nuclear pores, intranuclear position of tubulin-positive filaments, accumulation of Nrf2 in the cytoplasm, reduced nuclear content of Nrf2 in hippocampal neurons, and decreased pCREB levels in AD brains [45, 71, 111, 112] strongly suggest impaired nucleocytoplasmic trafficking in affected AD neurons. The gene discussed is NFE2L2; the disease is Alzheimer disease.