Endocardial specific ablation of Hand2 (heart and neural crest derivatives-expressed protein 2), a known CHD gene, in mice, results in cardiac malformations resembling the human condition tricuspid atresia and is caused by disruption to Notch-dependent cell-to-cell signalling and dysregulation of Vegfr3 function.134. The gene discussed is FLT4; the disease is coronary artery disorder.