Vitamin K3 was important for validating the role of KLF4-DYRK2 in the self-renewal of CML LSCs but might not be the appropriate drug for clinical translation because of toxicities to red blood cells, highlighting the need for novel small molecules with the same properties but enhanced safety in patients. This evidence concerns the gene KLF4 and chronic myelogenous leukemia, BCR-ABL1 positive.