Finally, the ubiquitin ligase Fbw7 modulates c-MYC protein levels in LICs, genetic loss of c-MYC abrogates BCR-ABL1-induced disease progression, and Fbw7 regulates CML-initiating cell survival via p53 activation60. This evidence concerns the gene FBXW7 and chronic myelogenous leukemia, BCR-ABL1 positive.