JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive: As single agents, JAK2 inhibitors specifically target CML LSCs without affecting normal HSCs, whereas the combination of JAK2 inhibition with dasatinib treatment efficiently eradicated TKI-resistant CML LSCs; thus, pharmacological inhibition of JAK2 can synergize with TKI therapy26,27.