There was a statistically significant difference in the immunoexpression of HIF-1α, MMP-2, VEGF/VEGFA, and VEGFR-2 proteins between the parenchyma of tumour cells and the stroma of tumour cells (Fig. 5A–D), where the parenchyma cells of AME showed a higher immunoexpression compared to the stromal cells. The gene discussed is HIF1A; the disease is neoplasm.