Angiogenesis and cellular invasion are complex multistage processes that begin with extracellular matrix (ECM) degradation caused by proteolytic enzymes, matrix metalloproteinases (MMPs), and, especially, cancer-associated MMP-2 and -96–9, which stimulate the release of angiogenic and growth factors in the basement membrane, such as the vascular endothelial growth factor (VEGF/VEGFA)10. Here, VEGFA is linked to cancer.