The methods used in this work, although indicating the expression of the studied proteins, limit the depth of our knowledge regarding the role of HIF-1α, MMP-2, VEGF, and VEGFR-2, as the expression of proangiogenic proteins in the centre of tumour epithelial islands suggest a secondary role of these proteins in the proliferation, survival, and invasion of ameloblastoma. Here, VEGFA is linked to neoplasm.